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Our task is to develop a suite of coherently defined bio-ontological relations that is sufficiently compact to be easily learned and applied, yet sufficiently broad in scope to capture a wide range of the relations currently coded in standard biomedical ontologies. Unfortunately the realization of this task is not a trivial matter. This is because, while the terms in biomedical ontologies refer exclusively to classes - to what is in reality - we cannot define what it means for one class to stand to another, for example in the relation, without taking the corresponding instances into account [ Core Harrington Jacket Sky captain Jack amp; Jones Clearance Ynj2TR70fs
]. Here the term 'instance' refers to what is in reality, to what are otherwise called 'tokens' or 'individuals' - entities (including processes) which exist in space and time and stand to each other in a variety of instance-level relations. Thus we cannot make sense of what it means to say unless we realize that this is a statement to the effect that each instance of the class stands in an instance-level part relation to some corresponding instance of the class .

This dependence of class-relations on relations among corresponding instances has long been recognized by logicians, including those working in the field of description logics, where the () form of definition we utilize below has been basic to the formalism from the start [ Cheap Sast Clearance Real Printed Racerback Top Fle by VIDA VIDA Pictures Cheap Online dPEyB
]. Definitions of this type were incorporated also into the DL-based GALEN medical ontology [ 15 ], though the significance of such definitions, and more generally of the role of instances in defining class relations, has still not been appreciated in many user communities.

It is also characteristically not realized that talk of classes involves in every case a more-or-less explicit reference to corresponding instances. When we assert that one class stands in an relation to another (that is, that the first is a subtype of the second), for example, that , then we are stating that instances of the first class are instances of the second. When we are dealing exclusively with relations there is little reason to take explicit notice of this two-sided nature of ontological relations. When, however, we move to ontological relations of other types, then it becomes indispensable, if many characteristic families of errors are to be avoided, that the implicit reference to instances be taken carefully into account.

We focus here exclusively on genuinely ontological relations, which we take to mean relations that obtain between entities in reality, independently of our ways of gaining knowledge about such entities (and thus of our experimental methods) and independently of our ways of representing or processing such knowledge in computers. A relation like is not ontological in this sense, as it links classes not to other classes in nature but rather to terms in a vocabulary that we ourselves have constructed. We focus also on general-purpose relations - relations which can be employed, in principle, in all biological ontologies - rather than on those specific relations (such as or employed by OBO's Sequence Ontology) which apply only to biological entities of certain kinds. The latter will, however, need to be defined in due course in accordance with the methodology advanced here.

Monday, October 2, 2017 at 10:23AM


Ripple’s XRP Ledger is a blockchain-based payment network that transfers funds between any type of currency within a few seconds with average transaction costs of a fraction of a penny. The core of this peer-to-peer network is an open source C++ application called rippled . Ripple’s goal is to supplant the world’s existing legacy payment networks. As such, scalability is a continuous goal. This document describes how the rippled team has integrated performance engineering into its development processes, and how this has contributed to throughput gains of over 1000%.

Performance engineering practices deliver benefits in addition to measurable performance gains. These include the ability to report on the capabilities of the software so that users can feel confident that their needs will be met by the system. Performance engineering informs capacity planning and optimal configuration of environments to support the application. Many performance problems are caught and addressed before customers notice them. As process automation improves, each change to the software can be quickly assessed for improvement or regression. This methodology also makes better use of developer time by helping choose the most effective tasks for improving performance. Any software project serious about supporting global scale should integrate performance engineering into its development cycle.

Performance Engineering Method

The practices adopted within Ripple are likely to be applicable to any software development project--particularly for enterprise transaction processing systems. Performance engineering implements tools and processes with which the team can continuously improve the product according to objective standards.


The main goal for this type of system is to maximize throughput while maintaining acceptable latency. The XRP Ledger processes all transactions in roughly 4 second intervals. Each transaction is cryptographically signed by the sender and is distributed to each peer on the network. The consensus process involves a set of trusted nodes called “validators” which must agree upon the transactions that are applied to each new ledger. Once submitted to the network, each valid transaction is committed as soon as the validators agree upon inclusion. The main goal of performance engineering at Ripple is to measure and improve transaction processing throughput of a set of trusted validators.

The best way to achieve this goal is through the scientific method: test the environment, analyze results, formulate a hypothesis, apply a fix, and repeat.

Test Environment

Testing entails macro-benchmarking. Macro-benchmarking most closely emulates real-world user activities against the system. This is contrasted with micro-benchmarking, which only tests a very limited subset of the system. Micro-benchmarks sometimes are useful, but care must be taken to not infer any capabilities for the system as a whole based upon micro-benchmarks alone. A contrived example of this type of flawed approach would be to count how many HTTP GET / requests can be handled by an application server and then report the results as being the server’s throughput capabilities. Obviously, an application server has many other components that are potential bottlenecks. One of the characteristics of a complex system is that it is not possible to know the behavior of the complete system under realistic load. Emulating the environment and its workload is the best way to observe realistic results before they occur in the live network.

The more complex the system, the more difficult it is to completely emulate its behavior in a test environment. Environment and test improvement are ongoing performance engineering activities. Don’t despair if testing doesn’t match the live environment 100%! In spite of this, many bottlenecks will be caught before ever being encountered in production.

The XRP Ledger is a peer-to-peer network that implements the Ripple Protocol . Every peer independently processes transactions submitted to the network. Each node relies on a set of trusted peers, called “validators,” for determining the status of the official ledger. Funds are transferred by way of submitting transactions which are then applied to the ledger. The goal of the testing described in this document is to determine the maximum throughput of a set of validator nodes.

Not all rippled nodes are validators. Some of them expose a RESTful server interface to clients for submitting transactions to the network and for retrieving historical data. These are referred to as “client handlers.” The benchmark environment is comprised of both validating nodes and client handlers as are present in the live network. In addition, a dedicated host is used to generate test load.

The environments used for tests as described in this document have the following characteristics:

The workload consists of sending payments of XRP (the crypto-currency native to the platform) between 5,000 accounts. Each second, a fixed number of transactions is submitted with a random sender giving 5 millionths of one XRP to a random receiver. This rate is sustained for twenty minutes. This workload is generated with a custom benchmark harness tool developed by Ripple. XRP is the native currency of the XRP Ledger: each transaction consumes a small amount of XRP as an anti-spam measure. Further, XRP can be used as a bridge currency to facilitate trades between any other asset types represented on the network.

Each test run is aborted by the benchmark software once either of 2 criteria fail:

Transaction volume is sustained at each level for 20 minutes, and is ramped up iteratively until either criteria fail. Maximum sustained throughput for each test is the rate prior to that which caused the failure. For example, if the network handled a load of 1500 transactions per second for 20 minutes, but failed after the rate increased to 1600/s, then the maximum sustained throughput is recorded as 1500/s.


In this context, profiling involves the collection of any type of statistics pertaining to the system under load. This can include resource utilization statistics such as displayed by top and iostat, custom logging messages from the application, as well as internal application statistics. A specific class of tools referred to as “profilers” is often used to provide internal application statistics, such as identifying the most-used function calls. But a broader meaning of profiling refers to collecting any performance-related facts occurring while the system is under load.

Here are some recommendations about profiling:

For profiling the XRP Ledger, basic operation system utilities top and iostat run on each host in the environment during each test. To isolate bottlenecks, rippled is instrumented with code that varies from simple log messaging all the way to a custom profiler. The main benefit of custom profiling code is that it provides precise control over what is reported based on specific characteristics of the application. The drawback is the effort required to implement and maintain the custom code. This is typical of “build vs buy/download” decisions in software development.

Profiling code built into rippled has suffered bit rot because it has not been used for over a year. There are plans to revive this code in the near future so that it can help with current rippled versions. But it is referred to here to illustrate its previous use in helping to scale rippled. The specific code used for profiling rippled is here: See u Soon Womens 5204014 Loose Fit Long Sleeve Cardigan See U Soon Get To Buy Latest Explore Online oVEWLM
. It was never merged into the main line of development, and so has never been implemented into production. A major benefit of this custom profiler is that it reports the time spent in functions that are called when a specific mutex is held. This lock is referred to as the “master lock,” and it tends to be a bottleneck to scalability. As mentioned previously, each rippled peer processes all transactions independently of its peers. Internally, the ledger is a monolithic data structure: it only allows one writer at a time to modify it. As such, when hardware resources such as CPU, memory, disk I/O and network are sufficient, the work of modifying the ledger data structure tends to be a limiting factor.

The custom profiling code uses a dedicated thread to periodically output JSON-formatted trace entries to a log file. Trace instrumentation is a powerful way to isolate bottlenecks. Depending on object lifetime, Trace objects can record any number of events. Each object is instantiated with a name and an optional counter. The name and counter are recorded in the first entry. Entries are ordered by timestamp to ensure sensible output. Trace objects that stay local to a function can be created on the stack. However, if passed to other functions or if placed in containers, shared pointers make the most sense. This entails function signatures being modified for each function to be called with a trace object. Functions with some callers that do not have trace objects can be overloaded to simply pass a default-constructed shared pointer of PerfTrace. Functions to add events to the object will only do so if the object exists. Timers are a special type of trace activity comprised of two events: a beginning and end. They are associated by the name. For proper time calculation, the name ending a timer must correspond to that of the beginning of the timer. What this all allows is for any particular code path to be instrumented such that any function calls in the code path can be timed to microsecond granularity. Each specific invocation of the code path’s Trace output is then logged. This is in contrast to most off-the-shelf profilers which aggregate function call usage over time, but comes at the cost of increased development effort.

Here is sample output showing a partial PerfTrace object:

All of the entries in the list correlate to the first entry, which is the 22nd instance in the code of the master lock being acquired. The specific thread id 18652. As the code path progresses, several functions are invoked with timers. For example, the “instantiate OpenView” function took 1870us. This particular trace object contains many more entries that correspond to instrumented activities during this particular acquisition of the master lock, but the output was truncated for brevity..

This profiling has proven to be very light-weight from a resource standpoint: it has not introduced the observer effect.

Identify Actionable Bottleneck

This is the most important phase: if nothing practical can be implemented, then no progress should be expected. The bottleneck metaphor is useful in this case: the narrowest part of a bottle (the neck) slows down the flow of fluid out of the mouth. Widening the neck so that the entire bottle becomes a cylinder will increase flow. While this is a useful metaphor, complex systems typically do not have a single component limiting performance. A more precise description of this phase is to identify a component, such as a hardware resource or function call, that if made more efficient, will increase throughput the greatest extent. This is an imprecise exercise. It involves informed guesswork.

Here are some suggestions to help make this phase successful:

Example: qalloc is good!

Here is an example of how this process was used to improve performance of the XRP Ledger. The work described took place in November, 2015. At the time, peak sustained throughput was about 500 transactions per second. There was plenty of CPU and other system resource headroom, so custom profiling described above was used to look for bottlenecks in the master lock.

Here is a report showing statistics for the functions taking the most time while holding the master lock. The test input was 500/s, which was close to the saturation point. The saturation point is where the application bottlenecks tend to become the most pronounced:

While not explicit from this report, each of the functions described are part of the call tree from the “modify” function at the top of the list. rippled applies transactions in batches while holding the lock. During the sample, there were 229.5/s transaction batches applied. Each averaged 3110us. There were 487/s individual transactions applied, which took 243us each.

Upon review, the rippled team found inefficiencies in the memory allocator used for data structures used within the most expensive functions. A new allocator (qalloc) was coded up and then tested. Here’s the profile:

Success! All of the functions took less time to complete and the number of batches increased. Per-transaction rate was about the same because the input rate for the test stayed the same. There was about 33% decrease in the overall time spent modifying the ledger! Here is the resulting commit into rippled: Use qalloc for RawStateTable and OpenView::txs_ .

10x+ Throughput Chronology

When performance testing began in February of 2015, the XRP Ledger sustained 80 transactions per second. Today, it’s up to 1500. The initial design of rippled was for scalability, and the underlying architecture has remained the same. Incremental improvement has been made over time as opportunities have been uncovered.


Performance engineering is about process. The heart of it is the scientific method. Reasoning in the abstract is insufficient to scale complex systems: inevitably, flaws in the system emerge and become noticeable only under load. The process described in this document can help any engineering team to get a head start on performance problems before they are noticed by users. Techniques described here are particularly useful for transaction processing systems because those tend to not scale simply by adding hardware. Ripple has adopted these techniques to help it become the most scalable payments-oriented blockchain network, and looks forward to continued improvement.

On HackerNews

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